IRBM is a scientific contract research organization (CRO) that stands at the forefront of drug discovery, leveraging a single, unified research facility, located in Pomezia (Rome), Italy, to accelerate team-based breakthroughs and improve efficiencies from initial concept to pre-clinical candidate.
With a history of contributing to several approved drugs, and its own internal pipeline of oncology and other therapeutic assets, IRBM is powered by deep collaborations and decades of expertise from leading global institutions. Our comprehensive in-house capabilities assist partners in achieving key milestones and progressing towards clinical readiness, positioning IRBM as a major player in driving innovation in the pharmaceutical and biotech fields.
Job Description
The peptide chemistry unit is seeking a talented peptide chemist with a strong and proven background in peptide & macrocycle chemistry, as well as expertise in organic synthesis. The successful candidate will be motivated and passionate about conducting high quality scientific research to advance internal and external peptide drug discovery programs. The candidate will be involved in the design of new molecules to progress structure activity relationship studies and the planning and execution of multi-step synthesis, purification and analytical characterization of complex peptides to achieve agreed upon objectives in a timely manner. The successful candidate will communicate effectively with internal and external collaborators and will work efficiently in a multi-disciplinary team environment.
Key responsibilities
Develop and execute synthetic strategies towards complex molecules using state-of-the-art synthetic methodologies.
Analyze and identify compounds using different purification and spectroscopic techniques.
Contribute to scientific strategies and goals within a project team setting.
Present data and reports on project status at individual and group meetings.
Conduct laboratory operations in a safe manner. Exhibit safety awareness and safe work practices; comply with all safety requirements according to Italian laws.
Expertise in peptide chemistry for the design/synthesis of complex peptides including peptide conjugates, macrocycles, small proteins
Design of synthetic routes and synthesis of amino acids and building blocks
Mastery of use of laboratory equipment with a preferential knowledge on the use of peptide synthesizers
Excellent knowledge of common purification techniques (HPLC, IEX, GPC) and analytical techniques (UPLC/HPLC and mass spectrometry)
Knowledge in structure elucidations of organic molecules by NMR and MS
Excellent communication skills, both verbal and written
Good knowledge of English is mandatory
Good team player abilities
Qualifications:
Master of Science Degree (Laurea Magistrale) in Chemistry or a related discipline with 5 years of experience doing peptide chemistry in a pharmaceutical or biotech environment.
PhD in Chemistry or a related discipline with one or more relevant postdoctoral experiences or with experience in a pharmaceutical or biotech environment.
Experience abroad would be considered a plus.
The position will be based at IRBM's headquarter in Pomezia (Rome), Italy
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