Testing Efficacy Of Cftr Correctors In Myogenic Cells From Lgmd2D/R3 Subjects

Organisation/Company: Università degli Studi di Padova Research Field: Biological sciences » Biology Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 15 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description The objective of this project is to verify the efficacy of small molecules belonging to the CFTR correctors family, in recovering a defective form of a-sarcoglycan (SG) carrying the amino acid substitution L66H. Activities include: Evaluating viability, proliferative index, and myogenic signature of the cells derived from the LGMD2D/R3. Testing the efficacy of the small molecules in rescuing SG in differentiated myotubes. Performing toxicity tests to evaluate the safety of the different small molecules. The postdoc must have competence and skills in cell biology (to grow, differentiate and treat myogenic cells) and in biochemistry to perform the requested analyses. Location: Italy Eligibility of fellows: country/ies of residence: OTHER Eligibility of fellows: nationality/ies: J-18808-Ljbffr