Study Of The Molecular And Anatomical Organisation Of Dopaminergic Circuits In Mouse Models Of []

Organisation/Company: Università degli Studi di Torino Research Field: Neurosciences Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 27 Jan 2025 - 13:00 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description CDKL5 deficiency syndrome (CDD) is a rare neurodevelopmental disorder belonging to the autism spectrum disorders. Patients manifest intellectual disability and motor problems, suggesting possible dysfunction of the midbrain dopaminergic system. As the impact of the loss of CDKL5 on this system is still poorly understood, the following project aims to study the dopaminergic system in mouse models of CDD (CDKL5-KO, CDKL5-E364X) by analysing (i) the morphological and molecular organisation of the synaptic contacts of the nigro-striatal circuits, (ii) the release of extracellular vesicles from cultured striatal neurons, (iii) and the role of striatal astrocytic glia, using cell biology and microscopy techniques. Finally, a panel of behavioural tests will be performed to assess sensorimotor responses and locomotor capacity in these animals. Eligibility of fellows Country/ies of residence: All Nationality/ies: All J-18808-Ljbffr