Role Of The Cystine/Glutamate Antiporter System (Xct) In Lung Metastasis

Organisation/Company: Università degli Studi di Torino Research Field: Medical sciences Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 27 Jan 2025 - 13:00 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure?
No Offer Description Breast cancer is the most common cancer among women and the leading cause of cancer-related death.
While early diagnosis and effective therapies have improved survival rates, some tumor cells (CTDs) can spread early to other organs, remain dormant, and reactivate years later, causing incurable metastases.
Our study focuses on the xCT molecule, which is highly expressed in breast cancer and inversely correlated with patient survival.
In murine models, xCT is crucial for metastasis, affecting both tumor invasiveness and communication with pre-metastatic tissues.
Additionally, xCT facilitates the release of extracellular vesicles (EVs), which are involved in forming the pre-metastatic niche.
This study aims to investigate the role of xCT in EV cargo and its impact on immunity, extracellular matrix, and endothelium, comparing EVs from cells with and without xCT expression to identify new therapeutic targets.
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