Role Of Smn2 Mrna Editing As Modulator Of The Clinical Severity Of Spinal Muscular Atrophy

Organisation/Company: Università Cattolica del Sacro Cuore
Research Field: Medical sciences » Medicine
Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3)
Country: Italy
Application Deadline: 15 Feb 2025 - 23:59 (UTC)
Type of Contract: To be defined
Job Status: Not Applicable
Is the job funded through the EU Research Framework Programme?
Other EU programme
Is the Job related to staff position within a Research Infrastructure?
No
Offer DescriptionmRNA editing is a physiological process occurring in transcripts of some genes.
In the literature, some studies have shown the editing of the mRNA of specific genes with functions in the central nervous system, particularly in neuronal plasma membranes.
We have shown that SMN1 and SMN2 mRNA, responsible and modulator of the clinical severity of spinal muscular atrophy (SMA), respectively, undergo editing.
In the present project, we will define the role of SMN2 mRNA editing as a modulator of phenotypic severity.
Additionally, we will try to identify the genes responsible for this process by developing cell models.

Eligibility of fellows: Country/ies of residence: EUROPE Eligibility of fellows: nationality/ies:
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