Organisation/Company: Università di Pavia Research Field: Neurosciences, Pharmacological sciences, Biological sciences Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 22 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description The project aims to validate new molecular targets to regulate neuroinflammatory and neuroprotective responses and assess a peripheral biomarker as an indicator of disease severity or treatment response. A new platform of in vivo models will be developed to study motor neuron diseases, focusing on: In vitro assays to analyze the molecular mechanisms of neurodegeneration; In vivo experiments on disease models, including pharmacology studies to validate new therapeutic approaches and the predictivity of new pharmacodynamic biomarkers. Advanced imaging techniques (MRI), ELISA analyses on biofluids, single-cell molecular profiling (single-cell RNAseq), and flow cytometry studies will be utilized. The recruited individual will also support project accounting management, secretarial activities for communication between units, and project reporting coordination with the manager. Main Requirements 1) Degree (with a course duration of not less than 4 years, as referred to in the pre-existing academic regulations pursuant to D.M. n. 509/1999) or post-graduate degrees (pursuant to D.M. n. 509/1999 and to n. 270/2004) awarded by Italian or foreign Universities recognized as equivalent. 2) Scientific or professional curriculum suitable for conducting the research activity. 3) If available, any Ph.D. title (Art 2- par. 1). Further Specific Assessable Qualifications Master's degree in a biological field and/or related fields; PhD (preferably enrolled in or completed a PhD program in a biological field or an equivalent qualification); Thesis on a topic related to the area of neurobiology with the application of key techniques for the project in question; Proven expertise in in vitro work (cell cultures) and the generation and manipulation of lentiviral vectors; Possession of certifications enabling preclinical in vivo experimentation on animal models with techniques relevant to the project's theme; Proven expertise in molecular biology and biochemistry techniques, flow cytometry and immunocytochemistry, and immunohistochemistry on histological preparations. Selection Process The application for admission to the selection procedure (dated and signed), the documents and publications considered useful for the evaluation must be submitted, under penalty of exclusion, electronically, by visiting the following web page: https://pica.cineca.it/unipv by choosing the "Assegni di ricerca" item and selecting the Competition Notice you have chosen. In order to register with the system, you must have an email address. Following the guidelines published in the procedure, the applicant must enter all the information required for the application, enclosing all documents in electronic .PDF format. The selection of candidates is carried out on the basis of qualifications, project and interview, supplemented by a test of knowledge of the foreign language (Art. 6 – par. 1). J-18808-Ljbffr