Località: Rozzano, IT, 20089 As part of the National Plan for Recovery and Resilience (Piano Nazionale di Ripresa e Resilienza, PNRR), IRCCS Istituto Clinico Humanitas has started the public selection procedures for recruitment under the projects regarding the Enhancement and strengthening of biomedical research in the NHS.
TITLE AND BRIEF PROJECT DESCRIPTION: Uncovering novel targets and pathways to enhance the efficacy of combination immunotherapy for lung cancer KMN309-CUP: E23C24000220006 Immunotherapies with immune checkpoint inhibitors (ICIs) have revolutionized the treatment of solid tumors, including lung cancer.
Combining ICIs with conventional chemotherapy has proven successful, but only in a subset of patients.
Although ICIs reinvigorate dysfunctional T cells against the cancer, acquired resistance occurs due to additional suppressive mechanisms, such as alternative checkpoints, inhibitory cell populations, and insufficient inflammation, among others.
However, knowledge in this area is limited.
Using a multitask approach that combines state-of-the-art technologies with the advantages of genetically engineered mice, models of primary carcinogenesis, and investigations in human samples, we will unravel the complex relationships between the immune system, the stroma, and the tumor.
Our aim is to discover major cellular and molecular mechanisms of resistance, which will be further explored in preclinical models of lung cancer to enhance tumor regression.
Job profile and brief description of activities required: Postdoctoral Scientist to join the Laboratory of Translational Immunology led by Dr. Enrico Lugli.
For more information, visit Enrico Lugli Group.
The successful candidate will be responsible for: Pursuing the program of work agreed with the Group Leader Designing and executing experiments Establishing procedures and developing new approaches; acquiring new skills Maintaining accurate records of experiments and reagents Preparing and presenting work at and attending weekly laboratory meetings.
Qualifications required: PhD in immunology, cancer biology or related fields.
Technical skills: Background in immunology, cellular and molecular biology, biochemistry Experience in immune profiling (cancer samples, human and mouse immune system) Experience in cell culture, flow cytometry, mouse handling and next generation sequencing Preferred candidate choice requirements: Familiarity with immune profiling, single-cell RNA sequencing, molecular biology, spatial transcriptomics, flow cytometry, tissue culture, cell-based assays and data analysis.
Highly motivated, detail-oriented, organized, flexible, and a team player.
Excellent written and spoken English.
Collaborate effectively with colleagues.
Learn and apply new skills.
Engage in constructive debate and support lab objectives.
Maintain a safe and compliant working environment.
On the basis of the profiles received and in the terms indicated by this notice, Humanitas will activate the selection process by inviting suitable candidates to participate in selection interviews, after verification of the cv and qualifications, which will be held in presence or in telematic mode.
The selection committee, composed of the Project Manager and the Human Resources Department, will take charge of the overall evaluation of the applications received and give feedback to the candidates within 60 days of the first interview.
Open Position (published): 07/08/2024 End Published: 06/09/2024 The notice is addressed to candidates in compliance with Dlgs 198/2006 and Dlgs 215/2003 and 216/2003.
Interested persons are invited to read the privacy notice ex art.
13 and 14 of EU Reg.
2016/679.
#J-18808-Ljbffr