col-wideJob Description:DescriptionProject: AIRC (Associazione Italiana per la Ricerca sul Cancro) IG2020 project "Hyaluronic acid-based carriers. Targeting mechanisms and application in a combination therapy approach"Commitment & contract: collaboration contract, duration: 24 monthsLocation: GenovaABOUT USAt IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society. Our Genoa headquarters are strictly interconnected with the other 11 centers around Italy and two outstations based in the US. We promote excellence in basic and applied research such as neuroscience and cognition, humanoid technologies and robotics, nanotechnology, materials for a truly multidisciplinary scientific experience.YOUR TEAMThe successful candidate will be part of the Research Line of Polymers and Biomaterials, headed by Prof. Nicola Tirelli and located in Genova, and will also collaborate with the center of Genomic Science, headed by Dr. Francesco Nicassio and located in Milano. The activity of the first Research Line is at the intersection between polymer and colloid chemistry, nanomaterials and drug delivery, while the second focuses on high-throughput experimental and -omics studies on non-coding RNAs.The AIRC project aims to use hyaluronic acid (HA)-based nanoparticles for the delivery of non-coding RNA and other payloads. The work programme for this specific post-doctoral position will predominantly focus on:a) the in vitro assessment of efficacy of the RNA-loaded nanomaterials in complex in vivob) the evaluation of the nanomaterials in non-tumour bearing murine models, evaluating pharmacokinetics, biodistribution, degradation of the nanoparticle components and payloads, overall safety;c) the in vivo efficacy of the RNA-loaded nanomaterials in tumour-bearing models, both as a single therapy and as a combination with known chemotherapic drugs;ESSENTIAL REQUIREMENTSUndergraduate degree in a biomedical or pharmaceutical discipline, medicine or veterinary medicinePhD in cancer studies, pharmacology, drug delivery, or cognate disciplineExperience in working with small laboratory animals, and in particular with IV administration.Experience in histology and ex vivo techniques (incl. fluorescence microscopy, blood analysis)Experience in mammalian cell culture and in standard cell biology techniques (PCR, Western, flow cytometryADDITIONAL SKILLSExperience with in vivo imaging techniques Experience with catheterization, microdialysis or stereotactic techniques Expertise in the analysis and delivery of non-coding RNA constructsExpertise in in vitro 3D cellular models (spheroids).Expertise in pharmacokinetic studies. Experience in the use of colloidal formulations in drug deliveryExperience in administering drugs/formulations through the cerebrospinal fluid.COMPENSATION & BENEFITSCompetitive salary package for international standards Private health care coverage Wide range of staff discountsCandidates from abroad or Italian citizens who permanently work abroad and meet specific requirements, may be entitled to a deduction from taxable income of up to 90% from 6 to 13 yearsWHAT'S IN FOR YOU?An equal, inclusive and multicultural environment ready to welcome you with open arms. Discrimination is a big NO for us!We like contamination and encourage you to mingle and discover what other people are up to in our labs! If paperwork is not your piece of cake, we got you! There's a specialized team working to help you with that, especially during your relocation! If you are a start upper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations.If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society!We stick to our values! Integrity, courage, societal responsibility and inclusivity are the values we believe in! They define us and our actions in our everyday life. They guide us to accomplish IIT mission!If you feel this tickles your appetite for change, do not hesitate and apply!
