Description Project: iRNA@IIT Commitment & contract: collaboration contract Location: CHT@Erzelli Genova About Us At IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society. Our Genoa headquarters are strictly interconnected with the other 11 centers around Italy and two outstations based in the US. We promote excellence in basic and applied research for a truly multidisciplinary scientific experience. Your Team You will be working in a multicultural group, where computational scientists and molecular biologists collaborate, each with their own expertise, to carry out a scientific activity with a shared research goal. We aim to understand how non-coding elements (DNA/RNA) and their epigenetic/epitranscriptomics modifications regulate 3D genome architecture and gene expression in stem cells and cancer models. To address this question, we use cutting-edge chromatin conformation assays such as Hi-C, Hi-ChIP and Pore-C in conjunction with other -omics techniques (e.g. ChIP-seq, TT-seq, scRNA-seq) and in combination with CRISPR-based genetic and epigenetic engineering tools. In-house produced data is then integrated with publicly available datasets with the final goal to understand how ncRNAs can induce and/or maintain 3D promoter-enhancer contacts, which ultimately determines the transcriptional program that dictates stemness and tumorigenesis. As a member of the FANTOM6 project, Postdocs in our lab will have the opportunity to attend and actively participate to the consortium meetings and will have ample opportunities for collaborations within the IIT and with extramural institutions to implement new workflows. Your main responsibilities will be: Analysis of next-generation sequencing data and integration of multi-omics data produced by different methods using computational tools and pipelines Interpretation of data and generation of figures for grant proposals and publications in peer-reviewed journals Essential Requirements A PhD in Bioinformatics, Computational Biology, Computer Science or in a related field Knowledge of programming languages such as R and Phyton and statistical methods applied to biosciences Proven ability to analyze next-generation sequencing data such as RNA-seq, ChIP-seq etc (previous experience in analysis of chromatin conformation data such as Hi-C will be considered a plus) Ability to work and think independently with a pro-active attitude, prone to team building and problem solving Strong publication record Good command of spoken and written English Compensation Package Competitive salary package for international standards Private health care coverage Wide range of staff discounts Candidates from abroad or Italian citizens who permanently work abroad and meet specific requirements, may be entitled to a deduction from taxable income of up to 90% from 6 to 13 years. What's In It For You? Anequal,inclusive, andmulticulturalenvironmentready to welcome you with open arms. Discrimination is a big NO for us! Welike collaborations andencourage you to mingle and discover what other people are up to in our labs! If paperwork is not your piece of cake, we got you! There is a specialized team working to help you with that, especially during your relocation. If you are a start upper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations. If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society! We stick to our values! Integrity, courage, societal responsibility and inclusivity are the values we believe in. They define us and our actions in our everyday life. They guide us to accomplish IIT mission. If you feel this tickles your appetite for change, do not hesitate and apply! #J-18808-Ljbffr
