APPLICATION CLOSING DATE: October 1st 2024 HT is an interdisciplinary research institute, created and supported by the Italian government, whose aim is to develop innovative strategies to promote human health through a multidisciplinary and integrated approach, combining genomics, computational and structural biology and neuroscience, as well as data and decision sciences.
The Human Technopole Foundation is looking for one highly motivated postdoc to work in the group of Prof. Giuseppe Testa, Neurogenomics Research Centre (Testa Group - Human Technopole).
The Testa Group focuses on the dynamics of brain disorders, with a strong emphasis on human experimental models and straddling multiple scales of analysis from single cell resolution to organismal function. Our research environment includes transformative facilities encompassing brain organoids automation, state of the art genomics and microscopy infrastructures along with a HT-wide architecture of high performance computing (HPC) attuned to the needs of contemporary computational biology.
We are seeking outstanding candidates passionate about the challenges of understanding human neuropsychiatric conditions in their authentic unfolding, harnessing high resolution epigenomics and the most advanced stem cell-based models, including assembloids and xenografts, to uncover actionable mechanisms and advance them towards translational applications.
Key tasks and responsibilities Conducting experiments in the area of stem cell neurobiology, combining cutting-edge methods from molecular biology, genome editing, biochemistry, cell biology and organoids, with a strong emphasis on advanced human cell culture pipelines, single cell and spatial genomics approaches and advanced imaging. Computational analysis to study neurodevelopmental dynamics at the single cell level. Analyse and integrate imaging data with molecular phenotyping of complex brain organoids models. Design, perform and analyse empirical data leveraging genetic and/or pharmacological multiplexed perturbations. Generating reliable data for publication in the projects to which s/he is assigned and record all data and results in specified forms (with Electronic Lab Notebooks). Perform well-documented bioinformatic analysis for internal and external single cell multi-omics datasets. Strongly interact with wet and dry scientists of the lab and also support other group members whenever needed. Communicating, explaining and contextualising results to a wide variety of collaborators with varying degrees of know-how. Mandatory requirements: A PhD degree in neurobiology or related areas; Fluency in English – HT is an international research institute. Preferential requirements: Track record in the following areas: 1)Advanced disease modelling (preferably with human pluripotent stem cell lines, organoids and primary neural cell cultures, including gene editing);
2) Molecular Biology (DNA and RNA manipulation, cloning, single cell and spatial omics, CRISPR perturbations);
3) Advanced chromatin technologies (Cut&tag/Cut&Run);
4) Histology and microscopy (including tissue processing techniques, clearing, dissociation and tissue processing, stainings, advanced microscopy).
Knowledge of programming languages applied to data analysis: Python (preferable), R, Java, JavaScript, C++, C#, MATLAB; Previous experience in the analysis and interpretation of single cell omics datasets; Experience with code versioning systems (e.g., git, SVN) and familiarity with container technologies (e.g., Docker, Singularity, Podman); experience working in a Unix/Linux environment and with bioinformatics workflow systems (i.e., Nextflow, Snakemake, CWL). Organizational and social skills: Strong organization skills and attention to detail; propensity to structure analytical steps in well-documented and reproducible workflows; Excellent problem-solving, analytical and critical thinking skills; collaborative attitude and ability to work in teams with colleagues of heterogeneous scientific backgrounds; Ability to manage competing priorities in a fast-paced environment and to work independently. Application Instructions Please apply online by sending:
a CV a motivation letter in English names and contacts of 2 referees For any inquiry about the call, please feel free to contact Prof. Giuseppe Testa, ****** (this email address should not be used to send applications).
Why Human Technopole HT seeks scientific excellence, we recruit the best scientific talents through international, open calls.
Our working environment is international, friendly and inclusive. Our scientists work together across disciplines on research topics of biomedical relevance, leveraging synergies between their diverse skill sets and methodological approaches.
We believe that highly diverse teams yield the best and most innovative results.
We engage in outward-facing scientific activities aimed at benefiting the national and international research community. Training is also at the heart of our activity, with initiatives and opportunities for our staff, including scientific courses, conferences and workshops.
Main benefits Welfare plans. Canteen service. Work-life balance provisions. Italian language training for foreigners. Maternity leave up to 1 year and other support for new parents. Counseling. Possibility of flexible working hours. Support for relocation. Tax benefits where applicable. Special consideration will be given to candidates who are part of the protected categories list, according to L. 68/99. The position is based in Milan. Number of positions offered: 1
Salary: 40K
Contract offered: CCNL Chimico Farmaceutico, Fixed-term 4 years - employee level.
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