Physico-Chemical Characterization And Biological Evaluation Of New Photoactive Ligands, With A []

Organisation/Company: Ministero dell'Università e della Ricerca MUR Research Field: Chemistry Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 16 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description By considering the relevance of amyloid diseases, at both the cerebral (such as Alzheimer's disease) and systemic extracerebral (e.g. immunoglobulin or transthyretin amyloidosis) levels, the project aims to identify new photoisomerizable compounds that can inhibit the formation of amyloid aggregates and determine fibrils disaggregation through irradiation with adequate wavelengths. The present project aims to: Experimental determination of the physico-chemical properties profile (lipophilicity, aqueous solubility) and stability in chemical and biological media (serum, microsomal preparations, cellular lysates) for a number of new chemical entities provided by the project partners. In vitro evaluation of the antiaggregant properties on selected amyloidogenic proteins of the new chemical entities. Eligibility of fellows: country/ies of residence: Italy, OTHER Eligibility of fellows: nationality/ies: J-18808-Ljbffr