Organisation/Company: Università di Pavia Research Field: Neurosciences, Pharmacological sciences, Biological sciences Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 22 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description The project aims to validate new therapeutic approaches for the treatment of high-grade gliomas, including chemoresistant glioblastomas. To achieve this objective, preclinical models of mice and rats will be developed using patient-derived cells. The following will be validated: new advanced imaging approaches (MRI) to monitor tumor cell invasiveness and alterations in the tumor microenvironment, the biodistribution of new tracers to identify cells responsible for recurrence, and the efficacy of multivalent drugs that modulate the immune response and counteract tumor progression. The research will be conducted according to Good Laboratory Practices (GLP) principles and will include methodologies such as flow cytometry, optical and confocal microscopy, MRI/confocal correlative microscopy, immunohistological analyses, and biomarker analyses in biofluids using ELISA. Main Requirements 1) Degree (with a course duration of not less than 4 years) or post-graduate degrees awarded by Italian or foreign Universities recognized as equivalent. Candidates must provide necessary documentation for qualification assessment. 2) Scientific or professional curriculum suitable for conducting the research activity. 3) If available, any Ph.D. title. Further Specific Assessable Qualifications 1) Master's degree in biology with a thesis related to neurobiology and application of key techniques for the project. 2) Skills in confocal microscopy and image analysis. 3) Familiarity with immunocytochemistry methods and immunohistochemistry on histological preparations. Selection Process The application for admission to the selection procedure (dated and signed), along with the necessary documents and publications, must be submitted electronically by visiting this web page . The selection of candidates will be carried out based on qualifications, project, and interview, supplemented by a test of knowledge of the foreign language. J-18808-Ljbffr