Complete Description Of Cofactor-Free Biological Oxidative Catalysis At Atomic Resolution Using[]

Organisation/Company: Università degli Studi di Padova Research Field: Biological sciences » Biology Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 16 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Our group will study an enzyme (urate oxidase, UOX) that degrades uric acid without external cofactors. Over the course of evolution, UOX has disappeared in humans, and it is often administered therapeutically for conditions that involve elevated uric acid levels (e.g., gout). Our approach to studying the enzymatic activation of molecular oxygen without cofactors addresses the complex nature of biological catalysis in a comprehensive manner, examining the most elusive atomic properties in combination with the most advanced and modern methodologies in structural biology. Activities Protein expression and purification X-ray crystallography Neutron crystallography Electron crystallography Eligibility of fellows Country/ies of residence: OTHER Nationality/ies: Not specified J-18808-Ljbffr