Characterization Of Tumor Microenvironment

OFFER DESCRIPTION Glioblastoma (GBM) is the most common brain tumor in the adult population and it is classified by the WHO as a Grade IV glioma.
GBM has a poor prognosis despite aggressive therapeutic approaches involving the combination of surgical resection, radiotherapy and chemotherapy.
Tumor microenvironmet (TME) of a numbre of solid tumors, including GBM, undergoes metabolic alterations and reshaping og signal molecules, growth factors and metabolites, have been identified as critical factors in inducingresistence to chemiotherapy and supporting immune escape.
The aim of the present study is to investigate, in preclinical in vitro and in vivo models, the crosstalk between TME and tumor cells, immune metabolic alterations and lactylation as a new metabolic reprogramming code in epigenetic modifications.
More Information Additional Information Eligibility criteriaEligible destination country/ies for fellows:
ItalyEligibility of fellows:
country/ies of residence:
EUROPEEligibility of fellows:
nationality/ies:
EUROPEWeb site for additional