Cancer Associated Fibroblasts In Melanoma: A Novel Approach To Target Tg2-Hsf1-Wnt Axis.

Organisation/Company: Università degli Studi di Roma Tor Vergata - Dipartimento di Biologia Research Field: Biological sciences Researcher Profile: Recognised Researcher (R2), Leading Researcher (R4), First Stage Researcher (R1), Established Researcher (R3) Country: Italy Application Deadline: 15 Jan 2025 - 23:59 (UTC) Type of Contract: To be defined Job Status: Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Tumors are multicellular systems characterized by reciprocal interactions between cancer cells and the Tumor Microenvironment (TME). This crosstalk plays a key role in the progression of cancer, and one of the most abundant cell types in the tumor stroma are the cancer-associated fibroblasts (CAFs). CAFs have the ability to remodel the extracellular matrix and produce cytokines and growth factors, which promote tumor growth. The research activity will focus on studying the processes that could promote melanoma development by examining the HSF1-Wnt pathway in CAFs. Moreover, the project aims to identify the molecular mechanisms by which stromal fibroblasts are reprogrammed to acquire tumor-promoting properties. Eligibility of fellows: Country/ies of residence: OTHER Nationality/ies: J-18808-Ljbffr